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| Preparation and Research of a Sulfide Ion Responsive Antiseptic Material |
| Received:July 13, 2018 Revised:October 25, 2018 |
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| DOI：10.7643/ issn.1672-9242.2018.10.011 |
| KeyWord:halloysite nanotubes sulfide ion responsive release complex film metronidazole |
| Author | Institution |
| ZHANG Hu-wei |
1. Key Laboratory of Marine Environmental Corrosion and Biofouling, Institute of Oceanology, Chinese Academy of Science, Qingdao , China;2. University of Chinese Academy of Sciences, Beijing , China;3. Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao , China |
| WANG Peng |
1. Key Laboratory of Marine Environmental Corrosion and Biofouling, Institute of Oceanology, Chinese Academy of Science, Qingdao , China;3. Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao , China |
| ZHANG Dun |
1. Key Laboratory of Marine Environmental Corrosion and Biofouling, Institute of Oceanology, Chinese Academy of Science, Qingdao , China;3. Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao , China |
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| Abstract: |
| Objective To prepare sulfide ion responsive antiseptic materials and study the effect of its packaging in different concentration of copper ion and the release behavior in different concentration of sulfide ion. Method Halloysite nanotubes were chosen as the carrier and characterized by transmission electron microscopy. Under vacuum conditions, metronidazole and ben-zotriazole (BTA) were loaded into the internal of the halloysite nanotubes in order. The sealing effect of metronidazole in the nanotubes under different concentration of copper ion and the release circumstance of metronidazole under different concentration of sulfide ion was tested with ultraviolet spectrophotometry. Results The higher copper ion concentration was, the better sealing effect of metronidazole was. When the copper ion concentration was 160 mmol/L, the sealing effect of metronidazole reached the best; the release concentration of metronidazole increased rapidly after the external concentration of sulfide ion reached 0.1 mmol/L and the release concentration of metronidazole didn’t change a lot when the concentration of sulfide ion was further increased. Conclusion The best encapsulation conditions of metronidazole in the nanotube were ensured by adjusting the concentration of copper ion to 160 mmol/L. The antiseptic materials can respond to the sulfide ions and the corresponding critical concentration is 0.1 mmol/L. |
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